江涛

江涛，博士，教育部优秀青年奖励计划的获得者，中国海洋大学药物化学专业学术带头人，教育部创新团队学术骨干；《精细化工》杂志编委。从事药物设计与合成研究；完成了多种海洋天然产物海洋生物碱杂多环的合成及其结构优化与构效关系研究；进行了基于糖结构的药物设计与合成及生物活性研究；两个化合物进入候选药物或系统临床前研究阶段。共主持、承担27项科研项目，项目转让4项；在Chem．Comm．，J．Med．Chem，E．J．Med．Chem．，Bioorg．Med．Chem等发表研究论文90余篇；授权国家发明专利20余项，申请PCT 专利6项。

1. 1.  海洋天然产物无海洋生物碱杂多环的合成及其结构优化与构效关系。

2. 2.  基于蛋白质结构的药物设计与合成及生物活性研究。

3. 3.  活性分子的糖基化、磷酸酯化、硼酸化等化学修饰和基于糖结构的药物设计与合成。

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中国药学会高级会员、《精细化工》杂志编委

药物合成反应（本科生课程）

高等有机化学（研究生课程）

1. 1.    Guanidine Modifications Enhance the Anti-Herpes Simplex Virus Activity of (E,E)-4,6-bis(styryl)- pyrimidine Derivatives in vitro and in vivo,Wei Wang#,*,Cuijing Xu,#,Jianqiang Zhang#,Jinpeng Wang, Rilei Yu,Dongping Wang,Ruijuan Yin,Wenmiao Li and Tao Jiang,*,British Journal of Pharmacilogy, 2019,https://doi.org/10.1111/bph.14918

2. 2.    Xin Jin,James Merrett,Sheng Tong,Bartholomew Flower,Jianling Xie,Rilei Yu,Shuye Tian,Ling Gao, Jiajun Zhao,Xuemin Wang,Tao Jiang*,Christopher G. Proud*,Design,synthesis and activity of Mnkl and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold,Euro.J. Med. Chem.,162(2019)735- 751
   

3. 3.    Aglycone Ebselen and β-D-Xyloside Primed Glycosaminoglycans Co-contribute to Ebselen-β-d-Xyloside- Induced Cytotoxicity,Yang Tang,Siqi Zhang,Yajing Chang,Dacheng Fan,Ariane De Agostini,Lijuan Zhang*,and Tao Jiang*, J. Med. Chem.,2018,61 (7), 2937-2948,
   

4. 4.    Wei Wang,Ruijuan Yin,Meng Zhang,Rilei Yu,Cui Hao,Lijuan Zhang*,and Tao Jiang*,Boronic Acid Modifications Enhance the Anti-Influenza A Virus Activities of Novel Quindoline Derivatives, J. Med. Chem., 2017,60(7),pp 2840-2852

5. 5.    Design and synthesis of neolamellarin a derivatives targeting heat shock protein 90,Long Jiang,Ruijuan Yin, Xueting Wang,Jiajia Dai,Jing Li,Tao Jiang*,Rilei Yu*,Euro.J.Med.Chem.,2017,135,24-33
   

6. 6.    Isothiouronium modification empowers pyrimidine-substituted curcumin analogs potent cytotoxicity and Golgi localization,Sheng Tong;Meng Zhang;Shixi Wang;Ruijuan Yin;Rilei Yu;Shengbiao Wan; Tao Jiang*;Lijuan Zhang*,Eur: J. Med. Chem.(2016),123,849-857

7. 7.    Pharmacokinetics in vitro and in vivo of two novel prodrugs of oleanolic acid in rats and its hepatoprotective effects against liver injury induced by CC14,Zongjiang Yua,,Weizhi Sun,Weibing Peng,GuoqiangLi,Tao Jiang*,Molecular Pharmaceutics (2016),13(5),1699-1710.
   

8. 8.    Design,Synthesis, and Biological Evaluationof NovelNon-Covalent Binding Quinazoline Glycoside Derivatives Targeting the Epidermal Growth Factor Receptor (EGFR) KinaseT790M/L858R Mutant, Renshuai Zhang,Shaopeng Chen,Xiaowei Zhang,Jing Ai,Shengbiao Wan,Meiyu Geng2*,Tao Jiang1*, RSC Advances,(2016),6(43),36857-36862.
   

9. 9.    Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1), Jiachi Chiou,Shengbiao Wan,Kin-Fai Chan,Pui-Kin So,Dandan He,Edward Wai-chi Chan,Tak-hang Chan,Kwok-yin Wong,Jiang Tao* and Sheng Chen*,Chem.Commun.,2015,51,9543-9546

10. 10.   Different cytotoxicities and cellular localizations of novel quindoline derivatives with or without boronic acid modifications in cancer cells, Ruijuan Yin, Meng Zhang, Cui Hao,Wei Wang,Peiju Qiu, Shengbiao Wan, Lijuan Zhang* and Tao Jiang*,ChemComm,(2013)
    

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Alternative and Complementary Therapies for Cancer 癌症备选治疗方法-整合方法及中药发现，Editor By Moulay Alaoui-Jamali, Publisher:Springer, Number Of Pages:722, Publication Date:2010-09-21,ISBN- 10/ASIN: 1441900195, Chapter 24 Marine Natural Products and their Synthetic Derivatives for Cancer Therapy,Page 613-644, Tao Jiang,Puyong Zhang,Shaopeng Chen, and Guoqiang Li

1. 1.    国家科技部国际合作重点项目（2013DFG32160）
   

2. 2.    国家自然科学基金（课题编号：21171154）

3. 3.    国家自然科学基金（课题编号：81373322）

4. 4.    “蓝色药库”技术创新工程，山东省重大科技创新专项（No．2018SDKJ0403—2）
   

5. 5.    国家新药创制科技重大专项，海洋生物来源化合物库建设（编号2017ZX09305—004）
   

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