刘珊

现任青岛海洋生物医药研究院海洋药物筛选与评价创新中心研发工程师，作为研发骨干，主要开展活性筛选和药理药效评价工作。

海洋药物活性筛选和药理药效评价

1.武娟,智锦锦,刘珊,卢娜,刘利,高江明,薛长湖,唐庆娟.多环芳烃光动力降解产物的细胞毒性检验[J].安全与环境学报, 2023, 23(02):603-610.

2.Xu X, Poulsen KL, Wu L, Liu S, Miyata T, Song Q, Wei Q, Zhao C, Lin C, Yang J. Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH). Signal Transduct Target Ther. 2022 Aug 13;7(1):287. doi: 10.1038/s41392-022-01119-3. PMID: 35963848; PMCID: PMC9376100.

3.Wu L, Zhao J, Zhang X, Liu S, Zhao C. Antitumor effect of soluble β-glucan as an immune stimulant. Int J Biol Macromol. 2021 May 15;179:116-124. doi: 10.1016/j.ijbiomac.2021.02.207. Epub 2021 Mar 3. PMID: 33667560.

4.Yang C, Ran Q, Zhou Y, Liu S, Zhao C, Yu X, Zhu F, Ji Y, Du Q, Yang T, Zhang W, He S. Doxorubicin sensitizes cancer cells to Smac mimetic via synergistic activation of the CYLD/RIPK1/FADD/caspase-8-dependent apoptosis. Apoptosis. 2020 Jun;25(5-6):441-455. doi: 10.1007/s10495-020-01604-6. PMID: 32418059.

5.Yu G, Wang Q, Liu S, Zhang X, Che Q, Zhang G, Zhu T, Gu Q, Li D. Methylsulfonylated Polyketides Produced by Neosartorya udagawae HDN13-313 via Exogenous Addition of Small Molecules. J Nat Prod. 2019 Apr 26;82(4):998-1001. doi: 10.1021/acs.jnatprod.9b00035. Epub 2019 Feb 20. PMID: 30785753.

6.Zhang C L , Liu S , Liu X C , et al. Discovery of novel inhibitors of anti-apoptotic Bcl-2 proteins derived from Bim BH3 domain[J]. Chinese Chemical Letters, 2017.

7.Wang X, Li Y, Liu S, Yu X, Li L, Shi C, He W, Li J, Xu L, Hu Z, Yu L, Yang Z, Chen Q, Ge L, Zhang Z, Zhou B, Jiang X, Chen S, He S. Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15438-43. doi: 10.1073/pnas.1412767111. Epub 2014 Oct 14. PMID: 25316792; PMCID: PMC4217423.

8.Liu S, Wang X, Li Y, Xu L, Yu X, Ge L, Li J, Zhu Y, He S. Necroptosis mediates TNF-induced toxicity of hippocampal neurons. Biomed Res Int. 2014;2014:290182. doi: 10.1155/2014/290182. Epub 2014 Jul 1. PMID: 25093162; PMCID: PMC4100394.

9.张明玲,刘珊,刘彦杰,王树林. 靶向p53的抗肿瘤药物研究进展[J]. 国际药学研究杂志, 2018, 45(2):88-93.

10.刘珊, 李成, 周海斌. 免疫激活骨髓间充质干细胞的旁分泌对成骨细胞功能的影响[J]. 免疫学杂志, 2014, 30(11):6.

1.实用新型专利：一种用于研发药物代谢的微流控芯片。发明人：刘珊，徐晓芳，武娟，刘利，李成，林成程，杨萌琳，高江明。专利号：ZL202122958211.4

2..实用新型专利：一种血管照射光动力治疗装置。发明人：武娟，李双江，刘珊，刘利，高江明。专利号：ZL202120420994.8

3.实用新型专利：一种光动力杀菌消毒冰箱。发明人：武娟，徐晓芳，刘珊，高江明，刘利。专利号：ZL202122876390.7

4.实用新型专利：一种应用于病原诊断的微流控芯片。发明人：徐晓芳，武娟，刘利，刘珊，林成程，柳晓春，杨萌琳。专利号：ZL202122892084.2

5. 实用新型专利：一种生物芯片点样仪。发明人：柳晓春，徐锡明，高江明，刘珊，刘利，武娟，袁文敏，张晓楠，赵俊。专利号：ZL202123062192.3